Abstract: Graphene exhibits ultrahigh electron mobility, excellent light transmittance, extremely low resistivity, and outstanding nonlinear optical properties, with well-established synthesis techniques. However, due to its in-plane isotropic C_6v crystal symmetry, graphene does not exhibit linear dichroism. A strategy of artificially induced uniaxial stretching is proposed in this paper, which successfully enables the controllable modulation of anisotropy in monolayer graphene supported on polydimethylsiloxane (PDMS) substrates. The variations in anisotropic transmittance under uniaxial tensile strain are characterized, achieving an anisotropy ratio of 4.7 at a 2% uniaxial strain. The results demonstrate that the artificial modulation of symmetry reduction in graphene is a promising strategy to impart extrinsic anisotropy to the material. This work pioneers a new avenue for endowing isotropic two-dimensional materials with anisotropic functionalities via artificial structural engineering.