Abstract: To improve the measurement accuracy and the stability of target image acquisition of electro-optical measurement system, a servo control technology based on model and sliding mode with super-twisting state observation for electro-optical measurement system is proposed in this paper. The established dynamic model analyzes most of the coupling disturbances in the system. The super-twisting state observer accurately estimates the remaining disturbances, and the switching sliding mode controller avoids system chattering and achieves rapid convergence. The simulation of the entire process of the electro-optical measurement system operation shows that the proposed control method can effectively resist environmental disturbances, maintain good stability and fast tracking speed of the system. It achieves high-precision measurement effects with an azimuth measurement error of 0.005° and an elevation measurement error of 0.03°, and ensures the high stability and high-precision monitoring and measurement capability of the electro-optical measurement system for the specified target.