Abstract: Aggregation-induced emission（AIE）phenomena have played more and more important role in the development of synthetic polymer chemistry, advanced optoelectronic materials and their applications, since the first report of Prof Tang in 2001. This presentation will introduce the physics basis and design principle of AIE-active molecules, including their classifications, structures, molecular mechanism and applications in fluorescent sensing, bioimaging and OLED etc. Also, Prof Tang will share his understanding on creativity and systematic research, and stimulate young investigators to focus on creative thoughts and the accumulation of scientific researches.